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Berberine 500 mg
Berberine 500 mg
  • Gluten Free
  • Vegetarian
  • Non-GMO
  • Vegetable Caps

Multi-faceted botanical compound that supports healthy glucose metabolism, cardiovascular wellness, gut health and more*

  • Promotes enhanced glucose and insulin metabolism*
  • Helps maintain cholesterol levels already in a normal range*
  • Supports healthy metabolic function*
  • Promotes intestinal health*

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Product Line Brochure Product Information Sheet (PDF)

Berberine is a botanical compound found in plants including barberry, goldenseal, Oregon grape, and tree turmeric. Used in Ayurvedic and Chinese herbal practices for hundreds of years, berberine's diverse mechanisms of action are also supported in modern research.

Its primary mechanism is its ability to activate the enzyme Adenosine Monophosphate-Activated Protein Kinase (AMPK), a central regulator of cellular energy homeostasis, while inhibiting Protein-Tyrosine Phosphatase 1B (PTP1B), a negative regulator of the leptin and insulin signaling pathways.

 

Research

  • Berberine has been shown to lower total and LDL cholesterol among diabetic participants in several controlled trials.
  • In controlled trials berberine reduced HbA1c levels in diabetic participants with comparable efficacy to metformin. Among participants with the metabolic syndrome berberine has been shown to reduce waist circumference and body weight, blood pressure, triglycerides, and improve insulin resistance compared to placebo, with similar benefits in women with Polycystic Ovary Syndrome (PCOS).
  • A clinical trial comparing standard therapy with or without berberine among patients receiving percutaneous coronary intervention showed improvements in multiple inflammatory markers.

References

  1. Vuddanda PR, et al. Opin Investig Drugs. 2010; 19(10):1297-307.
  2. Yu HH, et al. J Med Food. 2005; 8(4):454-61.
  3. Puertollano MA, et al. Top Med Chem. 2011; 11(14):1752-66.
  4. Zou K, et al. Acta Pharm Sinica. 2016. [advance online pub accessed 12.5.2016].
  5. Jayaprakasha GK, et al. Bioresour Techno. 2008; 99(10):4484-94.
  6. Manthey JA. Microcirculation. 2000; 7(6 Pt 2):S29-34.
  7. Ye L, et al. Life Sci. 2016; 166-82-91.
  8. Zhang Y, et al. J Clin Endocrinol Metab. 2008;93(7):2559-2565.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**
Berberine Hcl

(from Indian Barberry extract) (Berberis aristata root) 

 500 mg †
† Daily Value not established.
Other Ingredients:

vegetable cellulose (capsule), leucine, rice flour

This product is free of milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten.

This product is free of ingredients derived from genetically modified organisms (GMOs).



Suggested Use

Take 1 capsule 1-2 times daily as a dietary supplement, preferably with a meal or shortly after, or as directed by a health practitioner. Store in a cool, dry place.

Warnings

If pregnant, nursing, or trying to conceive, do not use this product. Consult your health practitioner before use if taking any medications. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.

 
Berberine 500 mg Label


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